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Perinatología y reproducción humana
versión On-line ISSN 2524-1710versión impresa ISSN 0187-5337
Resumen
MUNOZ-CUTILLAS, Agustín et al. Renal and multiorgan evaluation in infants with post-asphyxial hypoxic-ischaemic encephalopathy. Perinatol. Reprod. Hum. [online]. 2023, vol.37, n.1, pp.3-10. Epub 05-Jun-2023. ISSN 2524-1710. https://doi.org/10.24875/per.22000015.
Background:
Hypoxic-ischemic encephalopathy (HIE) secondary to perinatal asphyxia can affect any organ, worsening the prognosis.
Objective:
To describe renal and multiorgan involvement in moderate-severe HIE.
Material and method:
Newborns > 35 weeks diagnosed with moderate-severe HIE who required active hypothermia between 2010-2020 were included. To assess renal involvement, serum creatinine was measured in three different periods: at 48-72 hours, between the 3rd and the 7th day, and from the 7th to the 28th day.
Results:
A total of 135 patients were included, 112 (83%) with moderate and 23 (17%) with severe HIE. Significant differences were obtained when comparing median creatinine levels at 48-72 hours and between 3-7 days in both groups. There were no differences in creatinine according to the hypothermia method. Patients with severe HIE presented greater hemodynamic, respiratory, and hepatic involvement.
Conclusions:
Neonates with severe HIE present increased serum creatinine levels and greater multi-organ involvement than those with moderate HIE.
Palabras llave : Renal failure; Multiorgan involvement; Hypoxic-ischemic encephalopathy; Perinatal asphyxia.
