Abstract

ROMERO-MALDONADO, Silvia; ORTEGA-CRUZ, Manuel  and  GALVAN-CONTRERAS, Rafael. Early-onset neonatal sepsis in newborns to mother with chorioamnionitis: Case-controls study. Perinatol. Reprod. Hum. [online]. 2013, vol.27, n.4, pp.217-221. ISSN 2524-1710.

Introduction: Chorioamnionitis is common during pregnancy and associated with several perinatal complications, including postpartum infection and sepsis. Among the most frequent neonatal complications associated to chorioamnionitis are: preterm delivery, neonatal sepsis, chronic lung disease, brain injury secondary to infection, and other neurodevelopmental disorders. It is necessary to know what the risk is of early-onset neonatal sepsis in newborns to mothers with chorioamnionitis. Objective: Determine whether maternal chorioamnionitis has an association with early-onset neonatal sepsis. Methods: We performed a case-control study, in which we included 148 patients divided in two groups: group I, cases (n = 74) and group II, controls (n = 74). The sample size was calculated through difference of proportions. Results: The group of mothers with chorioamnionitis had less prenatal care, and their newborns had a larger number of infections and respiratory problems despite the indication of prophylactic antibiotic schemes. Conclusions: Newborn infants to mother with chorioamnionitis have an increased risk of early neonatal sepsis, despite the use of prophylactic antibiotics.

Keywords : Chorioamnioitis; early-onset neonatal sepsis; prophylactic antibiotics.

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