Archivos de neurociencias (México, D.F.)
versão impressa ISSN 0187-4705
Parkinson disease is a neurodegenerative disorder that affects 50/100,000 individuals in Mexico. Parkinson disease is characterized by reduction in dopamine content of the substancia nigra pars compacta resulting in 1055 of domamine-containing neurons. The postulated cause of the disease includes several processes: 1. a growth factor deficiency, such as nerve growth factor and brain-derived neurotrophic factor, cytokines which can prevent and protect neuronal cell death; which may regulate glial phenotype, T lymphocytes and Blymphocytes functions, and the surviving pathway signals; 2. dysfunction of the ubiquitin-proteasome system related to the histophatology of this disease; and 3. excitotoxic mechanisms, resulting in information of free radicals and the neuroinflammatory processes leading to autoimmunity or a failing immune response.
Palavras-chave : Parkinson; neuroinflammation; immunity; neurotrophins.