OBJECTIVE

To determinate if the ingestion of avocado in patients with metabolic syndrome diminishes endothelial dysfunction, oxidative stress and inflammation after ingesting hamburger meat.

MATERIAL AND METHOD

An experimental, longitudinal, randomized, prospective, crossed, open but blinded for outcomes evaluators trial was done from June to August 2018 in patients with metabolic syndrome in agreement to NCEP criteria. These patients were evaluated for endothelial function, inflammatory state and oxidative stress after two treatments: a hamburger meal and a hamburger meal plus avocado.

RESULTS

Fourteen patients with metabolic syndrome were included (11 men and 3 women). When ingesting hamburger meat, NO levels were raised compared when adding avocado that blunted this effect (p < 0.05). Hamburger decreased lipoperoxidation, effect that was inhibited by adding avocado (p < 0.05). The oxidative reactive species elevated their monocyte expression after hamburger ingestion; this effect was also inhibited by adding avocado (p < 0.05). No differences were found in the levels of adhesive molecules CD11b, CD18 in granulocytes and monocytes.

CONCLUSIONS

In an acute manner, avocado blocks the reduction of nitric oxide, diminishes formation of oxygen reactive species and blocks reduction of lipid peroxidation concentrations caused by a hamburger.

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