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Medicina interna de México
Print version ISSN 0186-4866
Abstract
BORRAZ-NORIEGA, Darío; ROBLEDO-PASCUAL, Julio César; TORRES-PEREZ, Jorge Alonso and FLORES-BARRIENTOS, Oscar Israel. Utility of nucleic acids detection GeneXpert tuberculosis (MTB/RIF) in respiratory and non-respiratory hospital reference samples. Med. interna Méx. [online]. 2018, vol.34, n.3, pp.381-387. ISSN 0186-4866. https://doi.org/10.24245/mim.v34i3.1994.
OBJECTIVE
To assess the sensitivity and predictive values of BAAR Ziehl-Neelsen and GeneXpert (MTB/RIF) for respiratory and non-respiratory samples in the general population and HIV-patients.
MATERIAL AND METHOD
A clinical open, not-random, prospective, descriptive and observational study was done from May 2016 to January 2017. Inclusion criteria were: Patients with radiological, clinical and epidemiological data that suggested tuberculosis within the diagnostic evaluation or risk of having it. Simultaneous sputum or extrapulmonary sample was taken for determination of Ziehl-Neelsen, GeneXpert MTB and culture; the crop was used as a gold standard.
RESULTS
There were included 120 patients, 88 (73.3%) men; the justification for performing the test was severe acute disease (n = 76, 63.3%), the risk factor with the highest prevalence was HIV-AIDS (n = 54, 45.5%) The highest percentage was respiratory (n = 75, 62.5%). The total of samples 89 (74.2%) were negative with respect to BAAR in contrast to GeneXpert and culture, which reported positive in 94 (78.3%).
CONCLUSIONS
The stable indicators evaluated in the GeneXpert test showed that it is a useful test especially in extralung samples of patients with HIV-AIDS.
Keywords : Tuberculosis; Tuberculosis drug resistant.
