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Medicina interna de México

Print version ISSN 0186-4866


GARCIA-ARIAS, Mario Ramón et al. Multicentric Castleman’s disease in a patient post-transplanted of bone marrow. Med. interna Méx. [online]. 2018, vol.34, n.2, pp.321-326. ISSN 0186-4866.

Castleman’s disease is a heterogeneous group of lymphoproliferative disorders (LPD’S), which has two types of presentation, unicentric (UCD) and multicentric (MCD) variety. Histologically it is characterized by lymph nodes with hyperplasia of germinal centers and increased vascularity. This article reports the clinical case of a 70-year-old female with previous autologous haematopoietic stem cell transplant. She arrived with asthenia, weight loss, abdominal pain and progressive dyspnea. A retroperitoneal tumor and right pleural effusion were found. Clinical approach and bibliographic review are reported, the incidence estimation for this disorder is 21-25 cases per million population, and only 14% of reported cases had a retroperitoneal presentation.

Keywords : Castleman’s disease; Lymphoproliferative disorders; Pleural effusion.

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