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Medicina interna de México

Print version ISSN 0186-4866

Abstract

RIOS-QUINTANA, Rogelio  and  ESTRADA-HERNANDEZ, Laura Olivia. Description and quantification of risks attributed to non-selective non-steroidal anti-inflammatory drugs consumed by Mexican population. Med. interna Méx. [online]. 2018, vol.34, n.2, pp.173-187. ISSN 0186-4866.  http://dx.doi.org/10.24245/mim.v34i2.2073.

OBJECTIVE

To analyze drug-adverse reactions related to the administration of non-selective non-steroidal anti-inflammatory drugs (NSAIDS) reported to the National Pharmacovigilance Center from 2011 to 2014.

MATERIAL AND METHOD

A study was done in which for the descriptive analysis was used the database of the National Pharmacovigilance Center 2011-2014 containing the drug-adverse reactions related to the administration of analgesic drugs coming from the different members of the Permanent Program of Pharmacovigilance, that were grouped according to: age and sex of patient, proceeding of the drug-adverse reaction, suspect active principle, severity and causality of reaction.

RESULTS

4553 drug-adverse reactions were related to the administration of an NSAID (3.9%). Metamizol was the most reported with 21.1% of the total of adverse reaction registered for this group of drugs.

CONCLUSIONS

Metamizol was the drug with more drug-adverse reactions reported. The dermatological reactions of importance (toxic epidermal necrolysis, Stevens-Johnson syndrome and Lyell syndrome) were higher reported with nimesulide.

Keywords : Non-steroidal anti-inflammatory drugs; Pharmacovigilance; Metamizol; Nimesulide.

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