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Medicina interna de México

Print version ISSN 0186-4866

Abstract

SALADO-BURBANO, JC.; ESKENAZI-BETECH, R.  and  HALABE-CHEREM, J.. Recurrent fevers. Med. interna Méx. [online]. 2017, vol.33, n.5, pp.634-647. ISSN 0186-4866.  http://dx.doi.org/10.24245/mim.v33i5.1559.

Recurrent fevers make up a significant yet underappreciated proportion (18-42%) of fevers of unknown origin. A group of recurrent fevers, known as autoinflammatory diseases or hereditary periodic fever syndromes occur due to a deregulated response of innate immunity, whereby an autoinflammatory reaction occurs resulting in tissue damage. Unlike autoimmune diseases, the autoinflammatory diseases are not associated to specific autoantibodies or major histocompatibility complexes (MHCs), but rather result from an aberrant activation of innate immune cells such as macrophages and neutrophils. Although the majority of cases begin during childhood, several are often diagnosed years after their debut or begin during adult life, justifying the need for internists to be familiar with these diseases. In this review we discuss the epidemiology, pathophysiology, clinical presentation, diagnosis and management of the main autoinflammatory diseases.

Keywords : recurrent fevers; causes; autoinflammatory diseases.

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