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Medicina interna de México
versión impresa ISSN 0186-4866
Resumen
GONZALEZ-GALVAN, LM et al. Hemophagocytic lymphohistiocytosis in a patient with rheumatoid arthritis secondary to septic shock. Med. interna Méx. [online]. 2017, vol.33, n.1, pp.121-125. ISSN 0186-4866.
Hemophagocytic lymphohistiocytosis is a hyperinflammatory syndrome and not an independent disease. Hemophagocytic lymphohistiocytosis is a terminal hyperinflammatory reaction that can occur in different conditions. The hemophagocytic lymphohistiocytosis genetic forms are due to a defect in the transport and operation of the cytotoxic granules of NK cells and cytotoxic T lymphocytes and are not only restricted in childhood. Acquired forms of hemophagocytic lymphohistiocytosis are found in infections, auto-inflammatory and autoimmune diseases, cancers and acquired immune deficiencies. The treatment is aimed at suppressing the activity of cytokines and eliminate infected and activated cells.
Palabras llave : hemophagocytic lymphohistiocytosis; rheumatoid arthritis; septic shock.