SciELO - Scientific Electronic Library Online

 
vol.36 número6Efecto sedante del midazolam genérico versus innovador en ratas WistarCarcinoma tímico en niños. Informe de dos casos índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

  • Não possue artigos similaresSimilares em SciELO

Compartilhar


Acta pediátrica de México

versão On-line ISSN 2395-8235versão impressa ISSN 0186-2391

Resumo

ALVAREZ-HERNANDEZ, Gerardo et al. Interferon gamma release assays for diagnosis of tuberculosis in pediatric population. Acta pediatr. Méx [online]. 2015, vol.36, n.6, pp.442-455. ISSN 2395-8235.

The interferon-gamma release assay (IGRA) is a novel method for the diagnosis of tuberculosis (TB), but its usefulness is uncertain in children.

Objective:

Examine the diagnostic capacity of QuantiFERON-TB Gold (QFT-G®) one of the IGRA commercial kits, in pediatric population of Sonora, Mexico.

Methods:

Cross-sectional design with 160 subjects less than 19 years old, in a hospital in Sonora, Mexico. Three groups were compared: one from patients with active TB (TBA), another one with latent TB (TBL) and one of hospital controls. The Stegen-Toledo criteria were the gold standard used. Multivariate logistic regression was performed to test the association between QFT-G® and selected predictors.

Results:

The sensitivity of QFT-G® in TBA was 76.9% and specificity 90.3%. For TBL, sensitivity was 25.0% and specificity of 98.6%. QFT-G® showed a moderate agreement (K = 0.574) with the standard. QFT-G® was associated with a chest radiograph suggestive of TB, (OR adjusted 4.37, 95% CI: 1.42, 13.42) and being a case of pulmonary TB (OR adjusted 6.15, 95% CI: 1.90, 19.92).

Conclusion:

The interferon-gamma release assay shows significant capacity to diagnose TBA and can be used to rule out TBL in the pediatric population.

Palavras-chave : Interferon-gamma release assay; Tuberculosis in childhood; Diagnosis.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )