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Salud mental

Print version ISSN 0185-3325


MORALES-MARIN, Mirna Edith et al. Effect of the polymorphism BDNF rs6265 G/A in Mexican outpatient children with autism spectrum disorders. Salud Ment [online]. 2018, vol.41, n.3, pp.117-121. ISSN 0185-3325.


The study of autistic spectrum disorders (ASD) at the genetic level is extremely important to understand their origin. In Mexico, there are few works addressed from this perspective.


We investigated the role of the Brain Derived Neurotrophic Factor (BDNF) gene variant rs6265 G/A for single nucleotide polymorphism analysis in Mexican children with ASD using a case-control association design.


We made a pilot study by case-control analysis adjusting by gender, age, and ancestry.


Our study found no association between the BDNF rs6265 gene polymorphism and ASD [p = .419, OR = 1.597 (.514, 4.967)]

Discussion and conclusion:

Worldwide, the results of case-control association studies with the rs6265 of BDNF are controversial and do not always replicate. This may be due to the ethnicity of our population and additional factors not studied in the present work. Our study suggests that the SNP rs6265 is not contributing for ASD susceptibility in Mexican population.

Keywords : BDNF; autism spectrum disorders; single nucleotide polymorphism; Mexican population.

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