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Salud Pública de México

versión impresa ISSN 0036-3634

Resumen

MOLINA-ROMERO, Camilo; ARRIETA, Oscar  y  HERNANDEZ-PANDO, Rogelio. Tuberculosis and lung cancer. Salud pública Méx [online]. 2019, vol.61, n.3, pp.286-291.  Epub 03-Mar-2020. ISSN 0036-3634.  https://doi.org/10.21149/10090.

Objective:

To describe the epidemiological studies about the relationship between lung cancer (LC) and pulmonary tuberculosis (Tb) and its possible molecular mechanisms.

Materials and methods:

We reviewed research databases in search of publications that included keywords LC and Tb.

Results:

It has been proposed that chronic inflammation in the lungs due to Tb could cause clastogenic activity in the DNA of bronchial epithelium. Another possibility is lateral gene transfer; since Mycobacterium tuberculosis (MTb) is an intracellular organism, bacterial DNA could integrate to bronchial epithelial cells inducing neoplastic transformation.

Conclusions:

There are epidemiological reports, particularly from Asian countries, which confirm a relationship between LC and Tb. MTb could play an active role in cellular transformation and it is important to elucidate the mechanism involved.

Palabras llave : tuberculosis; lung cancer; inflammation; EGFR; epidemiology.

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