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Salud Pública de México
Print version ISSN 0036-3634
Abstract
RODRIGUEZ-LARA, Vianey et al. Characteristics of non-small cell lung cancer: differences by sex and hormonal status in a Mexican population. Salud pública Méx [online]. 2019, vol.61, n.3, pp.265-275. Epub Mar 03, 2020. ISSN 0036-3634. https://doi.org/10.21149/10094.
Objective:
To analyze the differences in the clinico-pathological and molecular characteristics of non-small cell lung cancer (NSCLC) as well as the clinical outcome of patients by sex and hormonal status.
Materials and methods:
We performed a retrospective study among 1 104 NSCLC patients. Clinic-pathologic data was recorded and survival outcomes were compared between male and female sex patients, and further by pre and postmenopausal status in females.
Results:
Women were significantly more likely to be non-smokers (p<0.001), had higher frequency of wood-smoke exposure (p<0.001), EGFR-sensitizing mutations (p<0.001), had better performance status (p=0.020) and had a better overall survival (OS) compared to men (p=0.021). Differences were found also by hormonal status, postmenopausal women had a longer OS compared to premenopausal women (31.1 vs. 19.4 months p=0.046).
Conclusion:
Our results support the differences in lung cancer presentation by sex and also by hormonal status.
Keywords : lung carcinoma, non-small-cell; men; women; postmenopausal; premenopausal.
