SciELO - Scientific Electronic Library Online

vol.54 número4Jóvenes que ni estudian ni trabajan: salud mental, educación y empleoPrevalencia y riesgos asociados con pacientes adultos con asma de 40 años o más de la Ciudad de México: estudio de base poblacional índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Salud Pública de México

versão impressa ISSN 0036-3634


VARGAS, Mario H; CAMPOS-BEDOLLA, Patricia  e  SEGURA, Patricia. Inverse association between asthma and neural tube defects: a binational ecological study. Salud pública Méx [online]. 2012, vol.54, n.4, pp. 418-424. ISSN 0036-3634.

OBJECTIVE: Dietary intake of methyl donors such as folic acid prevents neural tube defects (NTD), but recent studies showed that it might also favor the development of asthma. In this work a possible ecological association between NTD and asthma was explored. MATERIAL AND METHODS: Data bases from Mexico and the United States (US) were reviewed to obtain information about geographical distribution (by state) and temporal trends (by year) of NTD and asthma. RESULTS: Those states with the lowest frequency of NTD had the highest frequency of asthma, both in Mexico (rS=-0.48, p=0.005) and US (rS=-0.39, p=0.005). Temporal trends also showed an inverse correlation in Mexico (1997-2007, rS=-0.73, p=0.01) and US (1979-1998, rS=-0.91, p<0.001). CONCLUSIONS: In both countries the frequency of asthma inversely correlated with the frequency of NTD, both in geographical distribution and annual trends, giving support to the possibility that methyl donors intake in diet or supplements is influencing the asthma frequency.

Palavras-chave : asthma; neural tube defects; anencephaly; spinal dysraphism; epigenomics; ecological studies; folic acid.

        · resumo em Espanhol     · texto em Espanhol     · pdf em Espanhol