Salud Pública de México
versión impresa ISSN 0036-3634
VALADEZ-GONZALEZ, Nina et al. CCR5-Δ32 allele involvement in the clinical evolution of HIV1+ patients in Yucatán, Mexico. Salud pública Méx [online]. 2011, vol.53, n.6, pp. 463-468. ISSN 0036-3634.
OBJECTIVE: CCR5-Δ32 allele frequency needs to be identified in HIV+ patients and exposed seronegative individuals in Yucatan, Mexico, to understand this mutation's relationship to infection and disease progression. MATERIAL AND METHODS: A total of 355 samples were analyzed: 62 from HIV+ patients, 51 from exposed seronegative individuals and 242 from general population. Infected patients were subdivided into a) normal progressors n= 49; b) slow progressors n= 10, and c) non-progressors n= 3. RESULTS: Genotype wt/Δ32 was identified in 17.7% of HIV+, 13.7% of exposed seronegative individuals and 6.2% of general population. Genotype Δ32/Δ32 was identified in 3.9% of exposed seronegative individuals. In infected patients, wt/Δ32 was identified in 10.2% of normal progressors, 30% of slow progressors and 100% of non-progressors. CONCLUSION: Genotype wt/Δ32 was observed in all non-progressing HIV+ patients, supporting its role in this group's disease development and clinical evolution.
Palabras llave : HIV-1; disease progression; CCR5 receptors; Mexico.