Abstract

SALAZAR-MEJIA, Patricia Guadalupe; TEJEDA-AGUIRRE, Celia Rosa  and  LOPEZ-MORENO, Héctor Samuel. Reaction of Leishmania (Leishmania) mexicana antigens by sera of patients with cutaneous leishmaniasis from Sinaloa, Mexico. Salud pública Méx [online]. 2010, vol.52, n.2, pp.165-169. ISSN 0036-3634.

OBJECTIVE: To detect Leishmania mexicana antigens reacting with sera of patients with cutaneous leishmaniasis (CL). MATERIAL AND METHODS: A crude extract of L. mexicana was used as antigen for 2-D Western blot using sera from 5 patients with CL and controls from Sinaloa, Mexico during 2008. RESULTS: Five antigens were detected in the five infected patients analyzed; their molecular weights and isoelectric points were: 26 kDa (pI 7.8), 27 kDa (pI 8.1), 28 kDa (pI 8.6), 29 kDa (pI 8.5) and 31 kDa (pI 9.0). CONCLUSION: New potentially immunodominant L. mexicana antigens were detected, suggesting that this parasite could be the species responsible for human infection in Sinaloa.

Keywords : Leishmania mexicana; antigens; cutaneous leishmaniasis.

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