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Salud Pública de México

versión impresa ISSN 0036-3634

Resumen

NAROD, Steven A. Screening for BRCA1 and BRCA2 mutations in breast cancer patients from mexico: the public health perspective . Salud pública Méx [online]. 2009, vol.51, suppl.2, pp. s191-s196. ISSN 0036-3634.

Genetic testing for mutations in BRCA1 and BRCA2 has potentially important public health implications. Through judicious testing of women believed to be at high risk for early-onset breast cancer and for ovarian cancer, it is possible to identify highly-predisposed women prior to the development of cancer. Current preventive options include preventive mastectomy, preventive oophorectomy, tamoxifen and oral contraceptives. The ability to offer genetic testing in Mexico on a widespread level is enhanced if the common founder mutations in the two genes can be discovered or if the cost of genetic sequencing is reduced. It is important that a genetic testing service be a multi-disciplinary effort with co-ordinated follow-up.

Palabras llave : breast cancer; hereditary; BRCA1; BRCA2; Mexico.

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