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Salud Pública de México

versión impresa ISSN 0036-3634


HERNANDEZ-RUIZ, Joselín  y  BECKER, Ingeborg. CD8+ cytotoxic lymphocytes in cutaneous leishmaniasis. Salud pública Méx [online]. 2006, vol.48, n.5, pp.430-439. ISSN 0036-3634.

OBJECTIVE: Review of the literature on the role of CD8+ T cell in the immune response against Leishmania species that cause cutaneous leishmaniasis. The role of macrophages, dendritic cells, CD4 T cells and NK cells has been extensively analyzed in leishmaniasis, yet very little knowledge has been gained on CD8+ T cells in this disease. Murine models of leishmaniasis suggest that CD8+ T cells participate through IFNg production, yet their cytotoxic capacity may also play a crucial role, as has been found in human disease. It is an enigma what mechanisms underlie the CD8+ T cell activation. It is possible that dendritic cells activate CD8+ T cells through mechanisms that include antigen traspresentation. A better understanding of CD8+ T cells in the immune response against Leishmania will undoubtedly provide new insights into the physiopathogenesis of the disease that could lead to new therapeutic approaches against leishmaniasis.

Palabras llave : cutaneous leishmaniasis; T CD8+ lymphocytes; immune response; cytotoxicity; apoptosis.

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