SciELO - Scientific Electronic Library Online

 
vol.46 número4Evaluación de la nitazoxanida en dosis única y por tres días en parasitosis intestinal índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • No hay artículos similaresSimilares en SciELO

Compartir


Salud Pública de México

versión impresa ISSN 0036-3634

Resumen

GALVEZ-GASTELUM, Francisco Javier; SANDOVAL-RODRIGUEZ, Ana Soledad  y  ARMENDARIZ-BORUNDA, Juan. Transforming growth factor-b as a therapeutic target. Salud pública Méx [online]. 2004, vol.46, n.4, pp.341-350. ISSN 0036-3634.

Transforming growth factor-b (TGF-b) family members include TGF-b, activins, and bone morphogenetic proteins (BMP). These proteins are structurally related cytokines secreted in diverse Metazoans. TGF-b family members regulate cellular functions such as proliferation, apoptosis, differentiation, and migration, and play an important role in organism development. Deregulated TGF-b family signaling participates in various human pathologies including auto-immune diseases, vascular disorders, fibrotic disease, and cancer. Ligand-induced activation of TGF-b family receptors with intrinsic serine/threonine kinase activity, triggers phosphorylation of the intracellular effectors of TGF-b signaling, the Smads proteins. Once these proteins are activated they translocate into the nucleus, where they induce transcription of target genes and regulate cellular processes and functions. Novel therapeutic strategies are currently being developed to correct alterations in pathologies that involve TGF-b as the main mediator.

Palabras clave : signal transduction; transforming grouth factor beta; smad; receptor.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons