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Salud Pública de México

Print version ISSN 0036-3634


BAPTISTA-GONZALEZ, Héctor Alfredo; ROSENFELD-MANN, Fany  and  LEISS-MARQUEZ, Teresita. Prevention of maternal RhD isoimmunization with anti-D gamma globulin. Salud pública Méx [online]. 2001, vol.43, n.1, pp.52-58. ISSN 0036-3634.

OBJECTIVE: To report our experience in preventing RhD maternal isoimmunization by using anti-D gamma globulin among Rh-negative women. MATERIAL AND METHODS: Between 1982 and 1995, immunologic and hematologic data were collected from all Rh-negative women seen at Mexico's National Perinatology Institute. Women at risk of Rh isoimmunization were given a prophylactic dose of 150 µg of anti-D gamma globulin. RESULTS: A total of 4 857 Rh-negative women were seen during the study period (4.85% of the total population of women seen at the Institute), 629 (13.0%) of whom developed RhD isoimmunization; 542 (86.2%) of these women were already isoimmunized when first seen at our Institute. Twenty-two women (3.5%) developed isoimmunization even after receiving a proper dose of anti-D gamma globulin. Prophylaxis was given to 2 605 women (53.6%); 2 039 received a single dose, and 475 two doses. Prophylaxis failed in 22 cases; four were women with multiple pregnancy and 18 developed obstetric pathologic conditions. CONCLUSIONS: The use of anti-D gamma globulin resulted in a reduction of maternal Rh isoimmunization to less than one case per 1 000 women. Failures to prevent isoimmunization were associated to additional obstetric conditions and to lack of adherence to prevention guidelines. The English version of this paper is available at:

Keywords : Rh isoimmunization [prevention & control]; Mexico.

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