Introduction:

The BCR-ABL fusion oncogene, a product of the Philadelphia chromosome t(9; 22), is relatively rare in children with acute lymphoblastic leukemia (ALL). Its presence is indicative of a poor prognosis.

Objective:

To determine the frequency of Philadelphia chromosome in children with ALL at the Pediatric Hospital of Sinaloa, Mexico.

Material and methods:

Nine-year records (2008-2017) of RT-PCR experiments for BCR-ABL of patients diagnosed with ALL were reviewed.

Results:

Of 138 patients with ALL, three Philadelphia chromosome positive patients (2.17%) were identified. These three patients were male, aged two to eight years, and were classified as having high-risk ALL. Although they have presented relapses, currently all three are alive and remain in treatment.

Conclusion:

The frequency of 2.17% of the Philadelphia chromosome in children with ALL that we found in this study, is similar to the Figures described in other countries.

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