Servicios Personalizados
Revista
Articulo
Indicadores
- Citado por SciELO
- Accesos
Links relacionados
- Similares en SciELO
Compartir
Revista mexicana de pediatría
versión impresa ISSN 0035-0052
Resumen
PLASCENCIA-PIMENTEL, Karen et al. Normal levels of urine neutrophil gelatinase-associated lipocalin (u-NGAL) in pre-term and term newborns at 24 and 72 hours of life. Rev. mex. pediatr. [online]. 2019, vol.86, n.6, pp.223-228. Epub 03-Dic-2020. ISSN 0035-0052.
Introduction:
The biomarker urinary neutrophil gelatinase-associated lipocalin (u-NGAL) has high excretion in case of ischemia the renal cell loop of Henle and collecting tubule; so far the normal values in neonates are controversial.
Objectives:
To determine u-NGAL values in healthy newborns at 24 and 72 hours of life, according to weeks of gestation (WG).
Material and methods:
Seventy neonates (25-32 WG n = 25, 33-35 WG n = 25 y 36-38 WG n = 10; 39-41 WG, n =10). The u-NGAL (ng/mL) levels were determined by chemiluminescence. Values are shown as median as well as minimum and maximum (median [min - max]).
Results:
u-NGAL levels were different in gestational age group at 24 and 72 hours. 24 hours = 25-32 WG = 18.2 [0.5-543.1], 33-35 WG = 22.3 [0.9-84.4], 36-38 WG = 10.1 [2.5-181.9], 39-41 WG = 20.4 [0-577] ; 72 hours = 25-32 WG = 47.2 [7.5-441.2], 33-35 WG = 33.0 [4.7-235.5], 36-38 WG = 27.7 [4.09-173.1], 39-41 WG = 17.8 [2.0-113.5].
Conclusion:
u-NGAL values in neonates seem to increase with gestational age and postnatal life hours; however, more studies are required to determine normal values.
Palabras llave : Urinary neutrophil gelatinase-associated lipocalin; urinary levels; neonates; pre-term; term; biomarker.