Resumo

ALVA-SANCHEZ, H. et al. Prototipo de microtomógrafo por emisión de positrones: resolución espacial y estudios metabólicos. Rev. mex. fis. [online]. 2010, vol.56, n.2, pp.175-182. ISSN 0035-001X.

During the past 4 years, the Medical Physics and Dosimetry Group at the Instituto de Física, UNAM, has developed a positron emission tomography prototype for small-animal imaging (microPET). The system is composed of pixelated, cerium-doped lutetium yttrium oxyort-hosilicate scintillation crystal arrays coupled to position-sensitive photomultiplier tubes. Detector electronic signals are processed by nuclear instrumentation modules and are digitized by a multichannel data acquisition board. The tomographic reconstruction is performed by filtered backprojection from a set of distortion- and nonuniformity- corrected projections taken at different angles. In this work, the reconstructed spatial resolution was evaluated from the line spread function with a mean value of 2.36 ± 0.44 mm. In addition, the first metabolic studies of 30 g, healthy mice, injected with ¹⁸F labeled fluorodeoxyglucose and sodium fluoride are reported. They display normal glucose uptake and skeletal structure, respectively. The microPET can be a useful tool for radiation detector physics research and its applications in nuclear medicine.

Palavras-chave : Positron emission tomography; PET; spatial resolution; small-animal.

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