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Revista de investigación clínica

versión On-line ISSN 2564-8896versión impresa ISSN 0034-8376


PEREZ-GARCIA, Luis F. et al. Frequency of Depression and Anxiety Symptoms in Mexican Patients with Rheumatic Diseases Determined by Self-Administered Questionnaires Adapted to the Spanish Language. Rev. invest. clín. [online]. 2019, vol.71, n.2, pp.91-97.  Epub 12-Abr-2021. ISSN 2564-8896.


The frequency of depression and anxiety symptoms in Spanish-speaking patients suffering from rheumatic conditions is unknown when using self-administered detection tools.


A single-center, cross-sectional survey including 413 patients (341 women) with well-defined rheumatic diseases was conducted. The patient health questionnaire-9 (PHQ-9) and generalized anxiety disorder (GAD)-7 questionnaires were used to detect depression and anxiety symptoms, respectively.


A total of 193 patients (46.7%) reported depression symptoms, and increased PHQ-9 scores were more frequently observed in women than in men (23% vs. 13%; p = 0.038), particularly in association with osteoarthritis, fibromyalgia, Sjögren’s syndrome, and osteoporosis. From 88 patients (21.3%) with PHQ-9 scores ≥ 10 points (moderate-to-severe depression symptoms), 27 (30.6%) were previously diagnosed to have depression and only four were under antidepressant treatment. Anxiety symptoms were observed in 168 patients (40.6%) and classified as moderate-to-severe by elevated GAD-7 scores in 68 subjects (16.4%). Of them, 12 (17.6%) were previously diagnosed with GAD, but only 4 (5.8%) were under therapy.


An unexpected and unusually high frequency of undiagnosed depression and anxiety symptoms was found in rheumatic patients. Self-administered screening tools adapted to the Spanish language are useful and may help clinicians to suspect these conditions.

Palabras llave : Depression; Anxiety; Mental health questionnaires; Rheumatic diseases.

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