Abstract

ROMANO-MORENO, Silvia et al. Population pharmacokinetics of carbamazepine in adults with epilepsy. Rev. invest. clín. [online]. 2005, vol.57, n.1, pp.38-49. ISSN 2564-8896.

The aim of the present study was to determinate the factors affecting carbamazepine (CBZ) clearance (CL) in adults with epilepsy using a mixed-effect model and sparse data collected during routine clinical care. The patient population comprised 104 adults receiving CBZ. A total of 161 CBZ steady state serum concentration samples were analyzed. Population CL was calculated by using NONMEM with a one compartment model with first-order absorption and elimination. The following covariates were tested for their influence on clearance (CL): total body weight, age, dose/day, sex, surface area (SA) and comedication with primidone (PRIM), valproic acid or phenytoin (DFH). The final regression model for carbamazepine clearance found best to describe the data was: CL = (0.614 SA + 0.0016 dose/day)(1 + 0.278 DFH)(1 + 0.326 PRIM)

Keywords : Carbamazepine; Pharmacokinetics; Adults; Population; NONMEM.

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