Resumen

RIVERA-TOLEDO, Evelyn; JIMENEZ-DELGADILLO, Alan Uriel  y  MANZANO-GAYOSSO, Patricia. Polyenic Antifungals. Action Mechanisms and their Applications. Rev. Fac. Med. (Méx.) [online]. 2020, vol.63, n.2, pp.7-17.  Epub 05-Mar-2021. ISSN 2448-4865.  https://doi.org/10.22201/fm.24484865e.2020.63.2.02.

The first compounds with specific antifungal activity were identified in the middle of the last century as a product of the secondary metabolism of bacteria of the order Actinomycetales, and their clinical use significantly diminished the morbidity and mortality associated with severe fungal infections. Many of such biosynthetic compounds are characterized by a chemical polygenic structure, with a variable number of carbon-carbon double bonds. Currently, besides polygenic antimycotics, there are other antifungal agents, such as the azole compounds, that have less toxicity in patients; however, cases of therapeutic failure with such compounds have been documented, therefore, the use of polygenics is still the best alternative in such cases. This review presents data about the properties and applications of antifungal-polygenic compounds using amphotericin B as a model.

Palabras llave : Amphotericin B; antifungal polyenes; ergosterol.

        · resumen en Español     · texto en Español     · Español ( pdf )