SciELO - Scientific Electronic Library Online

vol.57 número3La cocaína: sus efectos en la mujer embarazada y en el producto de la gestaciónTendencia de la mortalidad por trastornos mentales: un panorama epidemiológico en México (1980-2011) índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados




Links relacionados

  • No hay artículos similaresSimilares en SciELO


Revista de la Facultad de Medicina (México)

versión On-line ISSN 2448-4865versión impresa ISSN 0026-1742


CARRILLO ESPER, Raúl et al. Molecular basis of sepsis. Rev. Fac. Med. (Méx.) [online]. 2014, vol.57, n.3, pp.9-21. ISSN 2448-4865.

Sepsis continues to be a primary cause of high mortality and morbidity in critically ill patients. Despite constant growth in dedicated basic investigation and numerous clinical studies, no remarkable developments have been made for effective and innovative therapies. The physiologic disorders induced by sepsis are primarily due to the overwhelming immune response to invading pathogens rather than the direct effects caused by the pathogen.

Sepsis, understood as the systemic inflammatory response to infection is characterized by the unregulated production of proinflammatory cytokines. These mediators collectively lead to multiple organ failure and eventually to death. In this context, the role of inflammation in the physiopathology of sepsis, though not fully understood, is of critical importance. This review provides a perspective of the most current understandings of the molecular mechanisms during sepsis, which may provide an attempt to understand the nature of this unregulated response of the immune systems during sepsis.

Palabras llave : Sepsis; invading pathogens; infection.

        · resumen en Español     · texto en Español     · Español ( pdf )