Abstract

CARRILLO ESPER, Raúl et al. The importance of pharmacokinetic and pharmacodynamic parameters in antibiotic prescription. Rev. Fac. Med. (Méx.) [online]. 2013, vol.56, n.3, pp.5-11. ISSN 2448-4865.

In the treatment of critically ill patient, antibiotic choice and dosage are influenced by factors related to the pathogen, the drug and the patient's health status. The relationship of pharmacokinetic and pharmacodynamic parameters such as maximum concentration (Cmax), area under the curve (AUC) and minimum inhibitory concentration (MIC) can assist in decision-making to choose the drug and the correct dose. According to these parameters, antibiotics are classified into time-dependent and concentration-dependent. The first ones (betalactams, glycopeptides) could require adjustments in the infusion time; while concentration-dependent ones (aminoglycosides, fluoroquinolones) are based on the Cmax / MIC.

Keywords : Antibiotics; Pharmacodynamics; Pharmacokinetics; Area Under the Curve.

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