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Gaceta médica de México
On-line version ISSN 2696-1288Print version ISSN 0016-3813
Abstract
VILLAFUERTE-LEDESMA, Hilda M. et al. Association between vitamin D serum levels and inflammatory markers in patients on hemodialysis. Gac. Méd. Méx [online]. 2020, vol.156, n.6, pp.519-525. Epub May 27, 2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.20000004.
Introduction:
The relationship between 25-OH-vitamin D and the immune system in patients with chronic kidney disease is a subject of attention.
Objectives:
To assess the prevalence of vitamin D deficiency in patients on hemodialysis and to investigate the association between vitamin D, ultra-sensitive C-reactive protein (US-CRP), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR).
Method:
Cross-sectional study of 80 patients on hemodialysis, divided into two groups: a serum 25-OH-vitamin D level < 20 ng/mL was considered to be vitamin D deficiency and a serum level ≥ 20 ng/mL was regarded as normal. The relationship between the parameters was defined with Spearmans correlation analysis.
Results:
40 % of the patients had vitamin D deficiency. There were significant differences between groups in US-CRP (p = 0.047), NLR (p = 0.039), PLR (p = 0.042) and treatment with vitamin D analogues (p = 0.022). Vitamin D had a significant negative correlation with US-CRP (p = 0.026), NLR (p = 0.013) and PLR (p = 0.022).
Conclusions:
The prevalence of vitamin D deficiency was 40 %. The values of US-CRP, NLR and PLR were significantly higher in the presence of vitamin D deficiency. A significant inverse correlation was found between vitamin D levels and US-CRP, NLR and PLR.
Keywords : Vitamin D deficiency; Ultra-sensitive C-reactive protein; Neutrophil-to-lymphocyte ratio; Platelet-to-lymphocyte ratio.