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Gaceta médica de México
On-line version ISSN 2696-1288Print version ISSN 0016-3813
Abstract
CASTRO, Ana María et al. Effect of coinfection with influenza virus and bacteria on host damage. Gac. Méd. Méx [online]. 2020, vol.156, n.4, pp.270-275. Epub May 27, 2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.m20000397.
Background:
Influenza virus infection is often complicated by a bacterial infection, with this coinfection causing severe pneumonia. If not timely treated, the disease can cause death.
Objective:
To demonstrate, in animal models, that coinfection with influenza virus and bacteria that affect the respiratory tract causes multisystemic damage.
Method:
Six groups of mice were formed: a control group, one infected with the influenza virus, two infected with bacteria: Haemophilus influenzae and Streptococcus pneumoniae, respectively; and two co-infected with influenza virus and Haemophilus influenzae or Streptococcus pneumoniae, respectively.
Results:
Of the six groups of mice, only the group co-infected with influenza virus and Streptococcus pneumoniae showed damage to thoracic and abdominal organs. A decrease in serum cytokine levels was found in all study groups, which was more pronounced in the co-infected mice.
Conclusions:
The groups of mice infected with Streptococcus pneumoniae or influenza virus alone showed no damage, which indicates that coexistence of these infections caused the damage in the group of co-infected mice.
Keywords : Influenza; Bacterial infection; Coinfection; Pro-inflammatory cytokines.