Serviços Personalizados
Journal
Artigo
Indicadores
- Citado por SciELO
- Acessos
Links relacionados
- Similares em SciELO
Compartilhar
Gaceta médica de México
versão On-line ISSN 2696-1288versão impressa ISSN 0016-3813
Resumo
GALLARDO-RINCON, Dolores et al. Experience with the use of olaparib in patients with ovarian cancer. Gac. Méd. Méx [online]. 2019, vol.155, n.6, pp.585-589. Epub 25-Out-2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.19005494.
Introduction:
More than the twenty percent of ovarian cancers are hereditary, and most have BRCA mutations. The 30% of Mexican patients with the BRCA1 mutation have the BRCA1 gene exon 9-12del deletion founder mutation (BRCA1 ex9-12del). BRCA-mutated tumors are more sensitive to PARP inhibitors such as olaparib.
Objective:
To show the clinical experience on the use of olaparib at Instituto Nacional de Cancerología in Mexico.
Method:
Ovarian cancer patients treated with olaparib from November 2016 to December 2018 were studied, and their characteristics, clinical response, progression-free survival (PFS) and toxicities were described.
Results:
Nineteen patients were assessed, with BRCA1 mutation being found in 78.9%, out of which 21.1% were carriers of the ex9-12del founder mutation. The median of PFS was 12 months; for patients treated on second and third line it was > 15 months, and for those treated with a fourth and subsequent line it was 8.3 months. Patients with the founder mutation had better results. Toxicities were like those reported in previous studies.
Conclusions:
Olaparib offers greater PFS benefit as maintenance therapy after a first and second relapse. Patients with founder mutation have had sustained PFS.
Palavras-chave : BRCA mutation; Ovarian cancer; PARP inhibitor; BRCA1 founder mutation; Olaparib.