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Gaceta médica de México

versión impresa ISSN 0016-3813

Resumen

LEMUS-VARELA, María de Lourdes; ARRIAGA-DAVILA, José de Jesús  y  SALINAS-LOPEZ, Martha Patricia. Protein C congenital deficiency: A case report. Gac. Méd. Méx [online]. 2005, vol.141, n.3, pp.229-231. ISSN 0016-3813.

Protein C is a plasmatic protein that is synthesized by the liver with the help of vitamin K. It regulates thrombin formation and consequently prevents thrombosis. We present a case of a newborn male with change in the color of the right foot index finger who after 4 h showed cyanosis that reached malleolus level. Upon admission we observed generalized pallor, tachycardia and a necrotic lesion in the right foot. We suspected a septic process and thus administered cefotaxime, vancomycin and heparin. Platelet levels were 70,000mm3, thromboplastin 16/12 sec., partial thromboplastin 5829 sec. PC functionality 20% and protein S 100%. Even though the patient evolved favourably and showed partial recovery, an intratuberous amputation was needed. One year later a prosthesis was fitted. We need to carry out studies that support the use of PC monoclonal antibodies in order to offer better baseline treatment to patients with PC congenital deficiency and improve their quality of life.

Palabras llave : Protein C; congenital deficiency; thrombosis.

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