Article

 

One–Pot Regioselective Synthesis of 4–Bromopyrazole Derivatives Under Solvent Free Conditions

 

Heshmatollah Alinezhad,* Mahmood Tajbakhsh, and Mahboobeh Zare

 

Faculty of Chemistry, Mazandaran University, Babolsar, Iran. heshmat@umz.ac.ir.

 

Received June 2, 2011.
Accepted September 2, 2011.

 

Abstract

An efficient protocol for the one pot regioselective synthesis of 4–bromopyrazole derivatives from 1,3–diketones, arylhydrazines and N–bromosaccharin, in the presence of silica gel supported sulfuric acid as heterogeneous catalyst, under solvent free conditions, is reported.

Key words: 4–bromopyrazole, solvent free, N–bromosaccharin, 1,3–diketone, arylhydrazine.

 

Resumen

En este trabajo se informa de un método nuevo y eficiente para la síntesis regioselectiva y en una sola etapa de derivados del 4–bromopirazol, a partir de 1,3– dicetonas, arilhidracinas y N–bromo–sacarina empleando como catalizador ácido sulfúrico soportado en gel de sílice, en ausencia de disolvente.

Palabras clave: 4–bromopirazol, libre de solventes, N–bromosacarina, 1,3–dicetona, arilhidracina.

 

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