Resumo

OLVERA-GRANADOS, Claudia Patricia; LEO-AMADOR, Guillermo Enrique  e  HERNANDEZ-MONTIEL, Hebert Luis. Pancreas and β cells: Differentiation mechanisms, morphogenesis and endocrine cellular specification. Regeneration?. Bol. Med. Hosp. Infant. Mex. [online]. 2008, vol.65, n.4, pp.306-324. ISSN 1665-1146.

Diabetes mellitus type 1 is a multifactorial metabolic disease in which immunological mechanisms play an essential role. Once the disease is fully established, affected individuals are dependent upon exogenous insulin administration. Current research has identified a pancreatic population resembling stem cells features. This population of nestin-positive cells is activated under specific circumstances and opens the possibility of developing procedures for obtaining new β cells for the regeneration of the pancreatic islets. In this work we review the embryonic development of pancreas, pancreatic stem cells, the current models for the induction of stem cells in adult pancreas, the role of free radicals on the induction of new stem cells, and the current therapeutic procedures to improve the expression of these cells.

Palavras-chave : Diabetes mellitus; pancreatic stem cells; nestin; lesion models and current experimental therapies.

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