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Boletín médico del Hospital Infantil de México

versão impressa ISSN 1665-1146

Resumo

CORONEL- MARTINEZ, Diana Leticia; MALDONADO- VELAZQUEZ, Rocío; CARRENO- MANJARREZ, Roberto  e  GAMBOA- MARRUFO, José Domingo. Progressive myositis ossificans with good response to intravenous steroid treatment. Bol. Med. Hosp. Infant. Mex. [online]. 2005, vol.62, n.4, pp.256-260. ISSN 1665-1146.

Introduction. Progressive myositis ossificans is a rare cause of myositis in childhood, is an autosomal dominant inflammatory disorder that results in swelling of muscle followed by fibrosis and calcification. Material and methods. We present 2 cases in which, the main clinical manifestations were congenitally short great toes and thumbs; and hardening of the soft tissues; in both cases calcifications of the neck and the thorax were demonstrated by roentgenograms. The 2 patients received conventional management with diphosphonates and isotretinoine, with poor response to these therapies; because of this we decided to use 3 initial doses of intravenous methylprednisolone (30 mg/kg/doses), and after that, we continued the treatment with monthly applications of methylprednisolone. Results. With this therapy our patients improved; and this was evidenciated by diminishing of calcifications and by improvement in their functional status. Conclusion. In this paper we propose an alternative pharmacological therapy with intravenous methylprednisolone, looking for its antiinflammatory and immunosuppressive effects of steroids; mainly in patients with poor response to conventional treatments.

Palavras-chave : Progressive myositis ossificans; calcificated tissue; methylprednisolone.

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