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Revista alergia México
versão On-line ISSN 2448-9190
Resumo
MEDINA, Iris et al. Health related to quality life of patients with hereditary angioedema in Argentina. A multicenter study. Rev. alerg. Méx. [online]. 2023, vol.70, n.2, pp.64-71. Epub 28-Ago-2023. ISSN 2448-9190. https://doi.org/10.29262/ram.v70i2.1247.
Objective:
To describe health relaed quality of life in a cohort of stable adult outpatients with hereditary angioedema (HAE) with validated tools.
Methods:
An observational, cross-sectional, and descriptive study was performed, carried out in patients with hereditary angioedema, coming from the City of Buenos Aires and its provinces: Corrientes, Chubut, Entre Ríos and Santa Fe. The HAE-QoL and SF-12v2 health questionnaires were applied to assess the related quality of life. with health.
Results:
100 patients were included; median age: 41.5 years (range: 18-77); 65% were female, and 79% had type 1 HAE. Asymptomatic, mild, moderate and severe cases accounted for 6, 29, 38, and 27% of participants, respectively. Seventeen percent of patients were receiving long-term prophylaxis. Icatibant was the most frequent treatment for acute episodes. All health domains SF-12v2 scores were lower than expected in general population, excepting “vitality” and “physical functioning”. Total and all specific domains HAE-QoL scores were reduced. Differences between women and men and in every age-defined group were demonstrated for several specific domains.
Conclusions:
Health relaed to quality life was notably reduced in Argentinean patients with HAE, when implementing the HAE.QoL, and SF-12v2 questionnaries. The need for multidisciplinary strategies approaching this complex disease is highlighted.
Palavras-chave : Hereditary angioedema; Health-related quality of life; HAE-QoL; SF-12v2; Argentina.