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Cirugía y cirujanos
versão On-line ISSN 2444-054Xversão impressa ISSN 0009-7411
Resumo
MEJIA-BARRADAS, César M. et al. Regenerative treatment with umbilical cord mesenchymal stem cells from Wharton's jelly in chronic ulcer caused by dermolipectomy. Cir. cir. [online]. 2019, vol.87, suppl.1, pp.8-16. Epub 08-Fev-2022. ISSN 2444-054X. https://doi.org/10.24875/ciru.18000515.
Background:
Procedures to remove adiposities and skin, such as dermolipectomy, can develop wounds that are difficult to heal by conventional therapies. Mesenchymal stem cells are indicated as potential candidates for regenerative therapy in wounds, due to their multipotentiality, low immunogenicity, modulating capacity of inflammation and tissue modeling processes.
Case report:
Patient with dehiscent chronic ulcer secondary to dermolipectomy, who received cutaneous treatment with mesenchymal stem cells. The therapy induced scar formation and neovascularization, as well as the decrease of infiltrated leukocytes and proinflammatory cytokines. Mesenchymal cells are proposed as an interesting alternative for the treatment of postoperative lesions.
Palavras-chave : Chronic ulcer; Dermolipectomy; Mesenchymal stem cells; Regenerative medicine; Scarring; Inflammation.