BACKGROUND:

Squamous cell carcinoma of the bladder is a rare histologic variety of bladder cancer, accounting for 1.6-8% of cases.

CLINICAL CASE:

A 58-year-old woman presented with clot-forming gross hematuria and anemia. Cystoscopy revealed a 4-cm tumor on the anterior wall and fundus of the bladder and the histopathologic study from the transurethral resection of the bladder reported high-grade urothelial carcinoma with squamous cell differentiation, invasion of the muscle layer, and vascular and perineural permeation. Treatment was radical cystectomy plus the formation of an ileal pouch. The patient was released on postoperative day 5 with no complications. The pathology study result was moderately differentiated squamous cell carcinoma invading the perivesical tissue, confirming the previous diagnosis. Immunohistochemistry was positive for cytokeratin 5/6 and p/63. The patient was referred for adjuvant radiation therapy.

CONCLUSIONS:

The report of unusual types of bladder cancer (squamous cell carcinoma) is vitally important as a contribution to national statistics and to know the results of radical treatment.

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