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Archivos de cardiología de México

versão On-line ISSN 1665-1731versão impressa ISSN 1405-9940

Arch. Cardiol. Méx. vol.93 no.1 Ciudad de México Jan./Mar. 2023  Epub 24-Fev-2023

https://doi.org/10.24875/acm.21000093 

Research articles

Cardiogenic shock due to pulmonary thromboembolism: the role of surgical thrombectomy

Shock cardiogénico debido a tromboembolismo pulmonar: el papel de trombectomía quirúrgica

Consuelo Orihuela1 

Rosa Tzompantzi-Flores2  3 

José A. Hernández-Molina3 

Miguel Ayala-León1  * 

1Department of Cardiology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City

2Department of Cardiology, Hospital Beneficiencia Española de Puebla

3School of Medicine, Universidad Autónoma de Puebla, Puebla. Mexico


Abstract

A 53-year-old male patient with history of repaired hernia, who is admitted for 5 days of progressive dyspnea with diagnosis of abdominal sepsis, a computed tomography angiography was made, revealing pulmonary embolism in bilateral main pulmonary artery, and cardiac thrombectomy was performed.

Keywords Surgical thrombectomy; Paradoxical embolism; Right ventricle; Thrombus entrapped; Patent foramen ovale; Pulmonary embolism

Resumen

Paciente masculino de 53 años de edad con historial de reparación de hernia, quien fue ingresado por presentar 5 días de disnea progresiva con diagnóstico de sepsis abdominal, se le realizó una angiografía por tomografía computada, revelando embolismo bilateral arteria pulmonar principal, se realizó una trombectomía cardíaca.

Palabras clave Trombectomía quirúrgica; Embolismo paradóxico; Ventriculo derecho; Trombo atrapado; Foramen aval permeable; Embolismo pulmonar

Introduction

The foramen ovale is a communication that connects the right and left atrium in the fetal heart, allowing oxygenated blood to get to the fetal arterial circulation. When the foramen does not close completely, a patent foramen ovale (PFO) is formed1.

The PFO serves as a potential conduit for venous emboli to converge into the left atrium. A thrombus trapped passing through PFO is a very uncommon finding with no more than 200 occurrences reported in the literature.

We report a case of a straddling thrombus in a patient with a PFO that was associated with massive pulmonary embolism (PE) and treated surgically as emergency.

Materials and methods

A 53-year-old male presented to the emergency department with a 5-day history of progressive shortness of breath, asthenia, and shivering. He was seen weeks before at another facility for an incarcerated hernia that was surgically repaired with intestinal resection and ileostomy. Previously to medical discharged at this institution, E. coli was isolated at purulent secretion at surgical suture. He was initially diagnosed with abdominal sepsis which was treated with clindamycin.

Heart rate: 155, Blood pressure 90/50 mmHg, and SatO2: 86% SatO2 recovered: 96% and third and fourth heart sound gallop at physical examination.

His blood work revealed cardiac enzymes within normal limits (troponin of 0.02 ng/mL). His brain natriuretic peptide was elevated (436 pg/mL). Electrocardiogram showed sinus tachycardia. Computed tomography angiography of the thorax was done (Fig. 1A), which revealed PE in bilateral main pulmonary artery and segmental arteries involvement also a thrombus at inferior vena cava and right atrium (RA) was informed (Fig. 1B). No signs of deep venous thrombosis were shown on the computed tomography.

Figure 1 A: dilation of the pulmonary artery is observed as well as thrombi in both main branches. B: tricuspid insufficiency. The Doppler velocity signal is 4.6 m/sec and a ventricular-atrial gradient of 72.48 mmhg with an estimated systolic pulmonary pressure of 86 mmhg. C: time-velocity integral of RVOT of 7.6 cm that indates a low right ventricular output. 

Transthoracic echocardiogram showed normal left ventricular systolic function, moderate concentric hypertrophy, and paradoxical motion of the ventricular septum. The RA and right ventricle (RV) were dilated; this was associated with RV strain and moderately elevated pulmonary systolic pressure. A large serpiginous thrombus in the RA extending to the RV across the tricuspid valve and also an extension of this mass to the mitral valve is shown (Figs. 1C and 2A). Transesophageal echocardiogram showed a large thrombus floating in the RA with a segment being entrapped through a PFO extending to the mitral valve (Figures 3 and 4).

Figure 2 A: image of serpenteginous thrombus is observed that crosses the patent foramen ovale and goes to the mitral valve. B: thrombus is observed in the right atrium that enters the right ventricular outflow tract and passes through the patent foramen ovale. C: large thrombotic load is observed in both branches of the pulmonary arteries. 

Figure 3 Thrombus displacement by mitral valve. Is observed a wobble of the thrombus in the anterior leaflet of the mitral valve. 

Figure 4 Transesophageal echocardiogram: Thrombus at patent foramen ovale. 

A multidisciplinary team decided cardiac thrombectomy (due to high thrombotic burden, situation, and to recent surgical intervention as a contraindication for fibrinolysis) which was performed in addition to the closure of the PFO (Fig. 2B and C), the surgical technique is not described as it is not the purpose of this article.

The patient was transferred to the critical care unit and was discharged after 24 h being intubated, post-surgical fast-track was performed without requirement of inotropes and vasopressors. No complications like migration of thrombi to brain or other part of the body were presented.

Discussion

Our patient clinically presented with abdominal sepsis but has a high probability of PE. We must remember that sepsis, particularly when complicated by hypotension and shock, is considered a risk factor for venous thromboembolism, including upper and lower extremity deep venous thrombosis and PE2,3.

Paradoxical embolism is diagnosed at autopsy or at radiologic imaging when a thrombus that crosses an intracardiac defect is seen in the context of arterial embolic damage in end organs.

Most paradoxical embolisms typically occur at the time of PE, as in our patient, and are likely caused by the increase in right atrial pressure. Paradoxical embolism is uncommon (<2% of arterial embolizations). It is critical to diagnose a right heart thrombus, because it can embolize at any moment.

Recent reports indicate that early mortality rates after surgical embolectomy have improved over the years: in studies conducted by Takahashi et al. reported a 12.5% in-hospital mortality rate for 24 patients undergoing embolectomy4.

The overall mortality rate in patients with RHT has been reported as 28% and as high as 100% in untreated patients5,6.

Greelish et al. recorded low mortality in 15 patients treated with surgical embolectomy compared with 88 patients undergoing medical treatment. Early mortality was fairly similar (surgery 13% vs. medical 17%), but late mortality was lower at follow-up in surgical groups7, as the patient in our clinical case, supporting the decision for surgical intervention over fibrinolysis. Furthermore, thrombolysis was associated with an increased risk of stroke and reintervention at 30 days.

References

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3. Attia J, Ray JG, Cook DJ, Douketis J, Ginsberg JS, Geerts WH. Deep vein thrombosis and its prevention in critically ill adults. Arch Intern Med 2001[E-pub ahead of print];https://doi.org/10.1001/archinte.161.10.1268 [ Links ]

4. Takahashi H, Okada K, Matsumori M, et al. Aggressive surgical treatment of acute pulmonary embolism with circulatory collapse. Ann Thorac Surg 2012;94:785-91. 10.1016/j.athoracsur.2012.03.101 [PubMed] https://doi.org/10.1016/j.jtcvs.2010.12.030 [ Links ]

5. Chartier L, Béra J, Delomez M, et al. Free-floating thrombi in the right heart:diagnosis, management, and prognostic indexes in 38 consecutive patients. Circulation 1999 [E-pub ahead of print];https://doi.org/10.1161/01.cir.99.21.2779 [ Links ]

6. Rose PS, Punjabi NM, Pearse DB. Treatment of right heart thromboemboli. Chest 2002 [E-pub ahead of print];https://doi.org/10.1378/chest.121.3.806 [ Links ]

7. Greelish JP, Leacche M, Solenkova NS, et al. Improved midterm outcomes for type A (central) pulmonary emboli treated surgically. J Thorac Cardiovasc Surg 2011;142:1423-9. [PubMed] https://doi.org/10.1016/j.jtcvs.2010.12.030 [ Links ]

FundingThis research has not received any specific grant from public, commercial, or non-profit sector agencies.

Ethical disclosures

Protection of human and animal subjects. The authors declare that no experiments were performed on humans or animals for this study.

Confidentiality of data. The authors declare that they have followed the protocols of their work center on the publication of patient data.

Right to privacy and informed consent. The authors have obtained the informed consent of the patients and/or subjects referred to in the article.

Received: March 21, 2021; Accepted: March 08, 2022

* Correspondence: Miguel Ayala-León E-mail: terapia_intensiva_miguel@hotmail.com

Conflicts of interest

The authors declare that they have no conflicts of interest.

Creative Commons License Instituto Nacional de Cardiología Ignacio Chávez. Published by Permanyer. This is an open access article under the CC BY-NC-ND license