SciELO - Scientific Electronic Library Online

 
vol.92 número4Intervención psicológica a distancia para el tratamiento de la depresión en insuficiencia cardiacaRiesgo cardiovascular en la vida posnatal de hijos de mujeres con lupus eritematoso sistémico índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

  • Não possue artigos similaresSimilares em SciELO

Compartilhar


Archivos de cardiología de México

versão On-line ISSN 1665-1731versão impressa ISSN 1405-9940

Resumo

CONCEPCION-ZAVALETA, Marcio et al. Cardiovascular complications associated with acromegaly. A state-of-the-art. Arch. Cardiol. Méx. [online]. 2022, vol.92, n.4, pp.513-521.  Epub 09-Dez-2022. ISSN 1665-1731.  https://doi.org/10.24875/acm.21000339.

Acromegaly is a rare disease, mainly caused by a pituitary tumor secreting growth hormone. It is characterized by slow progression and is associated with a multisystemic involvement, being the cardiovascular system, one of the most involved, even reaching, more than 10 years ago, to represent the main cause of death. Cardiovascular complications develop as a result of elevated blood concentrations of growth hormone and insulin-like growth factor 1, which exert direct and indirect effects on the endothelium, large vessels, kidney and cardiomyocytes; causing arterial hypertension, valve disease, cardiac arrhythmia and a specific heart disease called acromegalic cardiomyopathy. After the literature overview related to the pathophysiology, clinical manifestations, diagnosis and treatment of cardiovascular involvement, we found that from a cardiovascular point of view, patients with acromegaly can range from an asymptomatic state to severe cardiac dysfunction, being the biochemical markers and imaging studies diagnostic tools that allow assessment the degree of cardiovascular disease in order to provide individualized treatment. The normalization of growth hormone and insulin-like growth factor 1 levels improves cardiovascular parameters, and therefore its prognosis.

Palavras-chave : Acromegaly; Heart; Heart diseases; Hypertension.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )