Resumo

BALDERRABANO SAUCEDO, Norma Alicia; VIZCAINO ALARCON, Alfredo; ESPINOSA ISLAS, Gonzalo  e  REYES DE LA CRUZ, Lorenzo. Evaluation of the effect of Carvedilol in children with dilated cardiomyopathy. Arch. Cardiol. Méx. [online]. 2008, vol.78, n.1, pp.52-59. ISSN 1665-1731.

Objective: To evaluate the effect of carvedilol administrated during 8 months in children with heart failure secondary to dilated cardiomyopathy. Methods: We initiated carvedilol in patients who, despite optimization of standard treatment, had persistent left ventricular ejection fraction < 40% and evaluated the systolic and diastolic left ventricular function before and after 4 and 8 months of treatment. Results: 19 patients were included in the study, 10 women; median age: 6.7 years and 17 ± 12.4 months after the diagnosis. The ejection fraction improved significantly from entry to eight months (median: 33.5 to 52.6%, p = 0.01) as did the shortening fraction (m: 14.8 to 25.8%, p = 0.01). The myocardial performance index abnormal in all 19 patients became normal in 5 at the end of study. In addition mitral Doppler flow which was altered in 9 improved in 3 and pulmonary venous flow abnormal in all patients improved in 13. Only 1 patient presented minimal adverse effects. Conclusions: Carvedilol added to standard therapy for dilated cardiomyopathy improves left ventricular function, is well tolerated, and has minimal adverse effects in childhood.

Palavras-chave : Heart failure; Dilated cardiomyopathy; Left ventricular function.

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