Resumo

KOVACIC, Peter; SOMANATHAN, Ratnasamy  e  INZUNZA, Michelle. Mechanism of Glutamate Neurochemistry: Electron Transfer and Reactive Oxygen Species. Rev. Soc. Quím. Méx [online]. 2003, vol.47, n.2, pp.146-150. ISSN 0583-7693.

Glutamate (Glu) undergoes metabolism to an imine derivative. We propose involvement of the conjugated α-iminocarboxylic acid in neurotoxicity and possibly in neurotransmission. Electrochemistry, captodative effect and bioactivity of related cyclic α-imino acids are relevant. There is also consistency with background literature of Glu indicating participation of oxidative stress, reactive oxygen species, and electron transfer. Alternatively, metal chelates of Glu and Glu imine may play a role. Various analogs of Glu imine were synthesized, namely, oxime and a cyclic model derived from cyclization of the intermediate hydrazone.

Palavras-chave : Glutamate; neurotransmission; toxicity; imine; electron transfer; reactive oxygen species.

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