Resumo

AYALA-MATA, Francisco et al. Antioxidants in asthma: polyphenols. Med. interna Méx. [online]. 2019, vol.35, n.2, pp.223-234.  Epub 30-Set-2020. ISSN 0186-4866.  https://doi.org/10.24245/mim.v35i2.2291.

Asthma is a disease related to oxidative stress. Practitioners of alternative medicine have used plants that have high concentrations of polyphenols in the treatment of patients with asthma. This paper reviews the use of non-vitamin antioxidants in asthma, with emphasis in polyphenols. A search was made in Google Scholar and in the RIMA database of Astra Zeneca with the keywords and phrases “asthma and flavonoids”, “antioxidant therapy in asthma”, “resveratrol and asthma” and “polyphenols and asthma”. We prioritized the search for experimental studies in animal models and studies with humans. There is a tendency to accept the favorable effects of polyphenols in asthma. Most of the information is more consistent in experimental work on animals than when comparing experiences among the few clinical studies in humans. The interpretation of studies from dietary experiences has the drawback that the type and concentration of polyphenols changes between populations and depends on geographical regions. It is advisable to design studies with a large number of people to evaluate the contribution of polyphenols in subjects with asthma in prophylaxis, crisis management and long-term disease control therapies.

Palavras-chave : antioxidants; oxidative stress; asthma; flavonoids; polyphenols.

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