Resumo

GOMEZ-ROMERO, P.; ALARCON-SOTELO, A.; RODRIGUEZ-WEBER, F.  e  DIAZ-GREENE, E.. Adiponectin as therapeutic target. Med. interna Méx. [online]. 2017, vol.33, n.6, pp.770-777. ISSN 0186-4866.  https://doi.org/10.24245/mim.v33i6.1672.

Adiponectin is an adipokine with ubiquitous actions, anti-inflammatory properties and antiapoptotic effects. Among its actions, this protein increases insulin sensitivity and reduces cardiovascular risk. A reduced level of adiponectin is associated with an increased risk of developing type 2 diabetes mellitus, metabolic syndrome, atherosclerosis and cardiovascular disease. Due to this evidence, the efforts of the basic and clinical studies have been directed to increase the understanding of the metabolism of this protein, as well as to develop methods to modulate its concentration and its bioactivity. The aim of this work is to review the metabolism of adiponectin and to explore its usefulness as a therapeutic target.

Palavras-chave : adiponectin; obesity; atherosclerosis; cardiovascular risk.

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