Resumo

MOSER, Brandy; MILLIGAN, Megan A.  e  DAO, Maria C.. The Microbiota-Gut-Brain Axis: Clinical Applications in Obesity and Type 2 Diabetes. Rev. invest. clín. [online]. 2022, vol.74, n.6, pp.302-313.  Epub 23-Jan-2023. ISSN 2564-8896.  https://doi.org/10.24875/ric.22000197.

Recent investigations highlight the importance of the gut microbiota and bacteria-derived metabolites as key components in obesity and metabolic health. The microbiota-gut-brain axis presents promising targets for future obesity treatments and prevention. However, the current state of evidence and existing clinical applications of the microbiota-gut-brain axis have yet to be summarized in a thorough review. Therefore, we sought to examine current evidence on the effect of lifestyle, dietary, pharmacological, and surgical interventions on the microbiota-gut-brain axis. In addition, this review highlights potential next steps in research toward characterizing the role of the microbiota-gut-brain axis in metabolic health, along with possible interventions to address obesity.

Palavras-chave : Gastrointestinal microbiome; Obesity; Brain-gut axis; Dysbiosis.

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