Resumo

CARRERA-DE LA CRUZ, Brian; OREA-TEJEDA, Arturo; GONZALEZ-ISLAS, Dulce  e  SANCHEZ-SANTILLAN, Rocío. Endothelial dysfunction as a consequence of COVID-19. Neumol. cir. torax [online]. 2022, vol.81, n.3, pp.178-182.  Epub 08-Dez-2023. ISSN 0028-3746.  https://doi.org/10.35366/111088.

COVID-19 (coronavirus infectious disease 2019) is caused by the virus SARS-CoV-2 and it has been a major health public problem worldwide, with complications and more than a million deaths around the world. The virus is part of the Coronaviridae family, and beta coronavirus (β-CoV) genus. Possess several proteins that codify the RNA and take action in the pathogenesis of the diseases. COVID-19 can occur as an asymptotic disease or with symptoms like cough, shortness of breath, fever, pneumonia, pulmonary edema, severe acute respiratory syndrome (SARS), in some cases neurological and gastrointestinal symptoms, even death. SARS-CoV-2 has several manifestations, in this review, we collect information for most recent articles about gastrointestinal manifestations, endothelial function, and the molecules involved in it, likewise, sepsis and inflammatory disease, and how the virus can act in that disease. SARS-CoV-2 causes endothelial dysfunction by infection and replication in the endothelial cells, additionally, by inflammatory interleukins release. Such as sepsis SARS-CoV-2 causes coagulopathy disorders; platelet aggregation, micro thrombosis, and severe complications, showing in a dimer D increased, and prothrombin time prolongation. Therefore, the aim of this article is to collect recent information available about the effect of SARS-CoV-2 on different organs, mainly gastrointestinal and endothelial function.

Palavras-chave : SARS-CoV-2; COVID-19; endothelial dysfunction; thrombosis; coagulation disorders.

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