SciELO - Scientific Electronic Library Online

 
vol.157 número5La asociación entre la resistencia a la insulina y la rigidez arterial en pacientes mexicanos sin diabetes mellitus tipo 2Validación de un tamiz precoz de preeclampsia en una población mexicana índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

  • Não possue artigos similaresSimilares em SciELO

Compartilhar


Gaceta médica de México

versão On-line ISSN 2696-1288versão impressa ISSN 0016-3813

Resumo

MORENO-ORTIZ, José M. et al. Matrix metalloproteinases 7, 8, 12, 13 gene haplotypes associated with colorectal cancer in a Mexican population. Gac. Méd. Méx [online]. 2021, vol.157, n.5, pp.548-553.  Epub 13-Dez-2021. ISSN 2696-1288.  https://doi.org/10.24875/gmm.21000051.

Background:

Matrix metalloproteinases (MMPs) are involved in tumor invasion and progression in colorectal cancer (CRC). Variants rs11568818, rs11225395, rs2276109 and rs2252070 have been associated with this neoplasm.

Objective:

To evaluate MMPs 7, 8, 12, and 13 haplotypes and their association with CRC.

Material and methods:

One-hundred and four patients and 112 healthy individuals were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP). For the association analysis, odd ratio and confidence interval values were calculated. Haplotype and linkage disequilibrium (LD) analysis was performed with Arlequin software, v3.5.

Results:

LD was present between rs2276109 and rs2252070. Haplotypes rs11568818(A)-rs11225395(T)-rs2276109(A)-rs2252070(A) and rs11568818(A)-rs11225395(C)-rs2276109(A)-rs2252070(G) were associated with CRC risk, and the haplotypes rs11568818(G)-rs11225395(C)-rs2276109(A)-rs2252070(A) and rs11568818(A)-rs11225395(T)-rs2276109(A)-rs2252070(G) with protection.

Conclusion:

Variants rs2276109 and rs2252070 showed linkage genic. Two haplotypes were found associated with the development CRC (ATAA and ACAG) and two were associated with protection (GCAA and ATAG). This study represents the first report on variants rs11225395 and rs2276109 frecuency in a Mexican population.

Palavras-chave : Colorectal cancer; Haplotypes; Matrix metalloproteinases; Mexican population.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )