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Gaceta médica de México
versão On-line ISSN 2696-1288versão impressa ISSN 0016-3813
Resumo
MARTINEZ-RAMIREZ, Daniel et al. Factors associated with cognitive impairment in a Mexican multicenter Parkinson’s disease cohort: a cross-sectional comparative study. Gac. Méd. Méx [online]. 2019, vol.155, n.6, pp.602-607. Epub 25-Out-2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.19005389.
Introduction:
Cognitive impairment is common in Parkinsons disease and represents a risk for dementia. Identifying associated factors will help implement early interventions and study its progression.
Objective:
To identify factors associated with cognitive impairment.
Method:
Cross-sectional study of 306 subjects with Parkinsons disease who were assessed for 12 months. Demographics and clinical variables were analyzed as explanatory variables, and cognitive impairment as outcome variable. Significant variables were used to construct a cognitive impairment predictive model.
Results:
Cognitive impairment was reported in 43.8%. Female gender (p = 0.001, odds ratio [OR] = 1.77), age at diagnosis (p < 0.001, mean deviation [MD] = 5.7), level of education (p < 0.001, MD = −2.9), disease duration (p = 0.003, MD = 1.7), MDS-UPDRS part III score (p < 0.001, MD = 9.7), presence of anxiety (p = 0.007, OR = 2.11), hallucinations (p = 0.029, OR = 2.27) and freezing of gait (p = 0.048, OR = 1.91) were predictors for cognitive impairment. The use of type B monoamine oxidase inhibitors was associated with less cognitive impairment (p = 0.001).
Conclusions:
Predictive factors that were consistent with those previously reported were identified. Prospective studies are required in order to clarify the effect of type B monoamine oxidase inhibitors on cognition.
Palavras-chave : Cognitive impairment; Non-motor symptoms; Parkinsons disease; Monoamine oxidase inhibitors.