Resumen

HUSSAIN, Fatma; SHAHID, Muhammad; ZULFIQAR, Saba  y  HAFEEZ, Javaria. Probing the Comparative Bioefficacy of Allium sativum L. Bulb through Different Solvents. J. Mex. Chem. Soc [online]. 2021, vol.65, n.4, pp.469-479.  Epub 28-Feb-2022. ISSN 1870-249X.  https://doi.org/10.29356/jmcs.v65i4.1532.

Allium sativum (garlic), an aromatic bulbous plant is one of the most vital and oldest authenticated herbs which has been utilized from ancient times as a traditional medicine. A. sativum has cardioprotective, antimicrobial, anti-inflammatory, antidiabetic, antioxidant and anticancer properties due to a large range of phenolic compounds and sulfur containing compounds. The current study was conducted to assess the antioxidant chemistry, and numerous bioactivities of A. sativum bulbs extracts in different solvents. Ethanol fraction was the most active antioxidant and showed maximum total phenolic content (16.18 g GAE/100 g), total flavonoid content (95.04 g CE/100 g) and free radical scavenging activity (75.50 %). Methanol (4 %) fraction exhibited maximum antiglycation activity. Aqueous, n-hexane and ethyl acetate fractions exhibited maximal (52 %, 24 % and 38 %) inhibitions of alpha-amylase, alpha-glucosidase and acetylcholinesterase respectively. In an antimicrobial assay, ethanol (59.05 %) and chloroform (72.92 %) fractions showed maximum inhibition of Pasturella multocida and Staphylococcus aureus strains respectively. n-butanol and n-hexane fractions showed maximum (31 %) antihemolytic activity and (20 %) thrombolytic activities respectively. A. sativum bulb extracts and fractions have noteworthy bio-efficacies that holds promise to be used as a source of natural drug to cure various disorders.

Palabras llave : Antioxidants; A. sativum; extraction solvents; flavonoid; antidiabetic; ethanol; phenols.

        · resumen en Español     · texto en Inglés     · Inglés ( pdf )