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Acta médica Grupo Ángeles
versión impresa ISSN 1870-7203
Resumen
CANO AGUILAR, Luis Enrique y RODRIGUEZ WEBER, Federico Leopoldo. Calciphylaxis. Acta méd. Grupo Ángeles [online]. 2020, vol.18, n.1, pp.50-60. Epub 22-Mar-2022. ISSN 1870-7203. https://doi.org/10.35366/92000.
Calciphylaxis is a syndrome characterized by the accumulation of hydroxyapatite crystals in the muscular layer of arterioles located in the dermis, subcutaneous and visceral tissue. This syndrome was first described by Selye back in 1962. The etiology of calciphylaxis is multifactorial and divided into two categories: uremic that presents in patients with renal replacement therapy and non-uremic, in patients with autoimmune and oncological diseases, as well as medical procedures. Clinically, star-shaped ulcers and gangrene with black eschar prone to infection are observed. The diagnosis of calciphylaxis is complicated due to unknowledge of the disease. In a study conducted in Japan in 2013, up to 60% of nephrologists are unaware of the existence of calciphylaxis. For its treatment, it is recommended a multidisciplinary team, where the treatment of choice are broad-spectrum antibiotics, opioid-based analgesics and surgical treatment. The prognosis is reserved for morbidity and mortality, because the survival is less than 40% One year after its diagnosis, so its recognition and timely treatment are of vital importance. Soft tissue focus sepsis is the most frequent cause of death.
Palabras llave : Calciphylaxis; sepsis; renal replacement therapy; gangrene.